Zentrallabor für Proteinanalytik (Protein Analysis Unit)

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Structure and Function of an Elongation Factor P Subfamily in Actinobacteria. Pinheiro,B., Scheidler,C.M., Kielkowski,P., Schmid,M., Forne,I., Ye,S., Reiling,N., Takano,E., Imhof,A., Sieber,S.A., et al. (2020) CellReports, 30, 4332–4342.e5.

Msp1 cooperates with the proteasome for extraction of arrested mitochondrial import intermediates. Basch,M., Wagner,M., Rolland,S., Carbonell,A., Zeng,R., Khosravi,S., Schmidt,A., Aftab,W., Imhof,A., Wagener,J., et al. (2020) Msp1 cooperates with the proteasome for extraction of arrested mitochondrial import intermediates. Mol. Biol. Cell, 31, 753–767.

Molecular Wiring of a Mitochondrial Translational Feedback Loop. Salvatori,R., Kehrein,K., Singh,A.P., Aftab,W., Möller-Hergt,B.V., Forne,I., Imhof,A. and Ott,M. (2020) Mol. Cell, 77, 887–900.e5.

A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation. Kochanova,N.Y., Schauer,T., Mathias,G.P., Lukacs,A., Schmidt,A., Flatley,A., Schepers,A., Thomae,A.W. and Imhof,A. (2020) Nucleic Acids Res, 225, 912.

Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes. Alabert,C., Loos,C., Voelker-Albert,M., Graziano,S., Forne,I., Reverón-Gómez,N., Schuh,L., Hasenauer,J., Marr,C., Imhof,A., et al. (2020)  CellReports, 30, 1223–1234.e8.

Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes. Alabert,C., Loos,C., Voelker-Albert,M., Graziano,S., Forne,I., Reverón-Gómez,N., Schuh,L., Hasenauer,J., Marr,C., Imhof,A., et al. (2020) CellReports, 30, 1223–1234.e8.

Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum. Böhm,K., Giacomelli,G., Schmidt,A., Imhof,A., Koszul,R., Marbouty,M. and Bramkamp,M. (2020) Nat Commun, 11, 1485–17.

Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1. Minderjahn,J., Schmidt,A., Fuchs,A., Schill,R., Raithel,J., Babina,M., Schmidl,C., Gebhard,C., Schmidhofer,S., Mendes,K., et al. (2020) Nat Commun, 11, 402–16.


Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake. Gaucher,J., Kinouchi,K., Ceglia,N., Montellier,E., Peleg,S., Greco,C.M., Schmidt,A., Forne,I., Masri,S., Baldi,P., et al. (2019) Proc Natl Acad Sci USA, 116, 25250–25259.

Distinct CoREST complexes act in a cell-type-specific manner. Mačinković,I., Theofel,I., Hundertmark,T., Kovač,K., Awe,S., Lenz,J., Forne,I., Lamp,B., Nist,A., Imhof,A., Stiewe T., Renkawitz-Pohl R., Rathke C., Brehm A. (2019) Nucleic Acids Res, 47, 11649–11666.

Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase. Lauterbach,M.A., Hanke,J.E., Serefidou,M., Mangan,M.S.J., Kolbe,C.-C., Hess,T., Rothe,M., Kaiser,R., Hoss,F., Gehlen,J., Engels G., Kreutzenbeck M., Schmidt S.V., Christ A., Imhof A., Hiller K., Latz E. (2019) Immunity, 51, 997–1011.e7.

Analog-sensitive cell line identifies cellular substrates of CDK9. Decker,T.-M., Forne,I., Straub,T., Elsaman,H., Ma,G., Shah,N., Imhof,A. and Eick,D. (2019) Oncotarget, 10, 6934–6943.

STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse. Gomez-Cabrero,D., Tarazona,S., Ferreirós-Vidal,I., Ramirez,R.N., Company,C., Schmidt,A., Reijmers,T., Paul,V.V.S., Marabita,F., Rodriguez-Ubreva,J., et al. (2019) Sci Data, 6, 256–15.

Determining histone H4 acetylation patterns in human peripheral blood mononuclear cells using mass spectrometry. Bux,E.M., Solis-Mezarino,V., Kuhm,C., Northoff,B.H., Karin,I., Klopstock,T., Holdt,L.M., Völker-Albert,M., Imhof,A. and Peleg,S. (2019) Clinical Mass Spectrometry, 10.1016/j.clinms.2019.08.001.

Quantification of Proteins and Histone Marks in Drosophila Embryos Reveals Stoichiometric Relationships Impacting Chromatin Regulation. Bonnet, J., Lindeboom, R.G.H., Pokrovsky, D., Stricker, G., Çelik, M.H., Rupp, R.A.W., Gagneur, J., Vermeulen, M., Imhof, A., and Müller, J. (2019). Dev Cell 1–20.

Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling. Harpprecht L, Baldi S, Schauer T, Schmidt A, Bange T, Robles MS, Kremmer E, Imhof A, Becker PB. A Nucleic Acids Res. 2019 May 31.

SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres. Gauchier M, Kan S, Barral A, Sauzet S, Agirre E, Bonnell E, Saksouk N, Barth TK, Ide S, Urbach S, Wellinger RJ, Luco RF, Imhof A, Déjardin J. Sci Adv. 2019 May 8;5(5):eaav3673.

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A, Allen A, Sum M, Obier N, Cottard F, Ulferts S, Preca BT, Hermann B, Maurer J, Greschik H, Hornung V, Einsle O, Perner S, Imhof A, Jung M, Schüle R. Nat Struct Mol Biol. 2019 May;26(5):361-371.

Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Bachmaier S, Volpato Santos Y, Kramer S, Githure GB, Klöckner T, Pepperl J, Baums C, Schenk R, Schwede F, Genieser HG, Dupuy JW, Forné I, Imhof A, Basquin J, Lorentzen E, Boshart M. Nat Commun. 2019 Mar 29;10(1):1421.

Multi-Reference Spectral Library Yields Almost Complete Coverage of Heterogeneous LC-MS/MS Data Sets. Ammar C, Berchtold E, Csaba G, Schmidt A, Imhof A, Zimmer R. J Proteome Res. 2019 Apr 5;18(4):1553-1566.

MIR sequences recruit zinc finger protein ZNF768 to expressed genes. Rohrmoser M, Kluge M, Yahia Y, Gruber-Eber A, Maqbool MA, Forné I, Krebs S, Blum H, Greifenberg AK, Geyer M, Descostes N, Imhof A, Andrau JC, Friedel CC, Eick D. Nucleic Acids Res. 2019 Jan 25;47(2):700-715.


Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability. van Emden TS., Forn M., Forné I., Sarkadi Z., Capella M., Martín Caballero L., Fischer-Burkart S., Brönner C., Simonetta M., Toczyski D., Halic M., Imhof A., Braun S. (2018). EMBO Rep.

Importance of Pyruvate Sensing and Transport for the Resuscitation of Viable but Nonculturable Escherichia coli K-12. Vilhena C., Kaganovitch E., Grünberger A., Motz M., Forné I., Kohlheyer D., Jung K. (2018). J Bacteriology.
Detection of Histone Modification Dynamics during the Cell Cycle by MS-Based Proteomics.
Völker-Albert MC., Schmidt A., Barth TK., Forné I., Imhof A. (2018). Methods Mol Biol.

Analysis of Histone Modifications by Mass Spectrometry. Völker-Albert MC., Schmidt A., Forné I., Imhof A. (2018). Curr Protoc Protein Sci.

Structural Architecture of the Nucleosome Remodeler ISWI Determined from Cross-Linking, Mass Spectrometry, SAXS, and Modeling. Harrer N., Schindler CEM., Bruetzel LK., Forné I., Ludwigsen J., Imhof A., Zacharias M., Lipfert J., Mueller-Planitz F. (2018). Structure.

Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals. Shah N., Maqbool MA., Yahia Y., El Aabidine AZ., Esnault C., Forné I., Decker TM., Martin D., Schüller R., Krebs S., Blum H., Imhof A., Eick D., Andrau JC. (2018). Mol Cell.

Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC. Schmähling S., Meiler A., Lee Y., Mohammed A., Finkl K., Tauscher K., Israel L., Wirth M., Philippou-Massier J., Blum H., Habermann B., Imhof A., Song JJ., Müller J. (2018).Development.

PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex. Link S., Spitzer RMM., Sana M., Torrado M., Völker-Albert MC., Keilhauer EC., Burgold T., Pünzeler S., Low JKK., Lindström I., Nist A., Regnard C., Stiewe T., Hendrich B., Imhof A., Mann M., Mackay JP., Bartkuhn M., Hake SB. (2018). Nat Commun.


Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells. Karg E., Smets M., Ryan J., Forné I., Qin W., Mulholland CB., Kalideris G., Imhof A., Bultmann S., Leonhardt H. (2017). J Mol Biol.

PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4. Saavedra F., Rivera C., Rivas E., Merino P., Garrido D., Hernández S., Forné I., Vassias I., Gurard-Levin ZA., Alfaro IE., Imhof A., Almouzni G., Loyola A. (2017). Nucleic Acids Res.

Coronin 1A., a novel player in integrin biology., controls neutrophil trafficking in innate immunity. Pick R., Begandt D., Stocker TJ., Salvermoser M., Thome S., Böttcher RT., Montanez E., Harrison U., Forné I., Khandoga AG., Coletti R., Weckbach LT., Brechtefeld D., Haas R., Imhof A., Massberg S., Sperandio M., Walzog B. (2017).Blood.

Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail. Ludwigsen J., Pfennig S., Singh AK., Schindler C., Harrer N., Forné I., Zacharias M., Mueller-Planitz F. (2017). Elife.

H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex. Saredi G., Huang H., Hammond CM., Alabert C., Bekker-Jensen S., Forné I., Reverón-Gómez N., Foster BM., Mlejnkova L., Bartke T., Cejka P., Mailand N., Imhof A., Patel DJ., Groth A. (2017). Nature.

ATM induces MacroD2 nuclear export upon DNA damage. Golia B., Moeller GK., Jankevicius G., Schmidt A., Hegele A., Preißer J., Tran ML., Imhof A., Timinszky G. (2017). Nucleic Acids Res.

Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion. Schinner C., Vielmuth F., Rötzer V., Hiermaier M., Radeva MY., Co TK., Hartlieb E., Schmidt A., Imhof A., Messoudi A., Horn A., Schlipp A., Spindler V., Waschke J. (2017). Circ Res.

NO Augments Endothelial Reactivity by Reducing Myoendothelial Calcium Signal Spreading: A Novel Role for Cx37 (Connexin 37) and the Protein Tyrosine Phosphatase SHP-2. Pogoda K., Mannell H., Blodow S., Schneider H., Schubert KM., Qiu J., Schmidt A., Imhof A., Beck H., Tanase LI., Pfeifer A., Pohl U., Kameritsch P. (2017). Arterioscler Thromb Vasc Biol.


Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression. Hintermair C., Voß K., Forné I., Heidemann M., Flatley A., Kremmer E., Imhof A., Eick D. (2016). Sci Rep.

Heptad-Specific Phosphorylation of RNA Polymerase II CTD. Schüller R.*, Forné I.*, Straub T.*, Schreieck A., Texier Y., Shah N., Decker TM., Cramer P., Imhof A., Eick D. (2016). Mol Cell.

Life span extension by targeting a link between metabolism and histone acetylation in Drosophila. Peleg S., Feller C., Forné I., Schiller E., Sévin DC., Schauer T., Regnard C., Straub T., Prestel M., Klima C., Schmitt Nogueira M., Becker L., Klopstock T., Sauer U., Becker PB., Imhof A., Ladurner AG. (2016) EMBO Rep.

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation. Metzger E., Willmann D., McMillan J., Forné I., Metzger P., Gerhardt S., Petroll K., von Maessenhausen A., Urban S., Schott AK., Espejo A., Eberlin A., Wohlwend D., Schüle KM., Schleicher M., Perner S., Bedford MT., Jung M., Dengjel J., Flaig R., Imhof A., Einsle O., Schüle R. (2016) Nat Struct Mol Biol.

In situ detection of histone variants and modifications in mouse brain using imaging mass spectrometry. Lahiri S., Sun N., Solis-Mezarino V., Fedisch A., Ninkovic J., Feuchtinger A., Götz M., Walch A., Imhof A. (2016) Proteomics.

MALDI imaging mass spectrometry as a novel tool for detecting histone modifications in clinical tissue samples. Lahiri S., Sun N., Buck A., Imhof A., Walch A. (2016) Expert Rev Proteomics.

Combinatorial Histone Acetylation Patterns Are Generated by Motif-Specific Reactions. Blasi T., Feller C., Feigelman J., Hasenauer J., Imhof A., Theis FJ., Becker PB., Marr C. (2016). Cell Syst.

A Quantitative Proteomic Analysis of In Vitro Assembled Chromatin. Völker-Albert MC., Pusch MC., Fedisch A., Schilcher P., Schmidt A., Imhof A. (2016). Mol Cell Proteomics.


Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II. Voss K., Forné I., Descostes N., Hintermair C., Schüller R., Maqbool MA., Heidemann M., Flatley A., Imhof A., Gut M., Gut I., Kremmer E., Andrau JC., Eick D. (2015) Transcription.

Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells. Schulz AM., Stutte S., Hogl S., Luckashenak N., Dudziak D., Leroy C., Forné I., Imhof A., Müller SA., Brakebusch CH., Lichtenthaler SF., Brocker T. (2015) .J Cell Biol.

DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex. Kellner, M., Rohrmoser, M., Forné, I., Voss, K., Burger, K., Mühl, B., Gruber-Eber, A., Kremmer, E., Imhof, A., and Eick, D. (2015). Experimental Cell Research.

DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination. Qin, W., Wolf, P., Liu, N., Link, S., Smets, M., Mastra, F.L., Forne, I., Pichler, G., Hörl, D., Fellinger, K., et al. (2015). Cell Res. 25, 911–929.

Methylation of histone H3 lysine 9 occurs during translation. Rivera, C., Saavedra, F., Alvarez, F., Díaz-Celis, C., Ugalde, V., Li, J., Forne, I., Gurard-Levin, Z.A., Almouzni, G., Imhof, A., et al. (2015). Nucleic Acids Res 43, 9097–9106.

The Epoxyeicosatrienoic Acid Pathway Enhances Hepatic Insulin Signaling and is Repressed in Insulin-Resistant Mouse Liver. Schäfer, A., Neschen, S., Kahle, M., Sarioglu, H., Gaisbauer, T., Imhof, A., Adamski, J., Hauck, S.M., and Ueffing, M. (2015). Molecular & Cellular Proteomics 14, 2764–2774.

Two distinct modes for propagation of histone PTMs across the cell cycle. Alabert, C., Barth, T.K., Reverón-Gómez, N., Sidoli, S., Schmidt, A., Jensen, O.N., Imhof, A., and Groth, A. (2015). Genes Dev. 29, 585–590.

Global and specific responses of the histone acetylome to systematic perturbation. Feller, C., Forné, I., Imhof, A., and Becker, P.B. (2015).  Mol. Cell 57, 559–571.


PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells. Jilg CA, Ketscher A, Metzger E, Hummel B, Willmann D, Rüsseler V, Drendel V, Imhof A, Jung M, Franz H, Hölz S, Krönig M, Müller JM, Schüle R. Oncotarget. 2014 Dec 10. [Epub ahead of print]

Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation. Saksouk N, Barth TK, Ziegler-Birling C, Olova N, Nowak A, Rey E, Mateos-Langerak J, Urbach S, Reik W, Torres-Padilla ME, Imhof A, Déjardin J. Mol Cell. 2014 Nov 20;56(4):580-94

The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase. Heublein M, Burguillos MA, Vögtle FN, Teixeira PF, Imhof A, Meisinger C, Ott M. Mol Biol Cell. 2014 Nov 1;25(21):3342-9.

LSD1 controls metastasis of androgen-independent prostate cancer cells through PXN and LPAR6. Ketscher A, Jilg CA, Willmann D, Hummel B, Imhof A, Rüsseler V, Hölz S, Metzger E, Müller JM, Schüle R. Oncogenesis. 2014 Oct 6;3:e120.

Bioinformatic analysis of proteomics data. Schmidt A, Forne I, Imhof A. BMC Syst Biol. 2014 Mar 13;8(Suppl 2):S3. Epub 2014 Mar 13.

Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits. Brami-Cherrier K, Anzalone A, Ramos M, Forne I, Macciardi F, Imhof A, Borrelli E. Mol Psychiatry. 2014 Jul 15. doi: 10.1038/mp.2014.67.

Identification of novel Drosophila centromere associated proteins. Barth TK, Schade GO, Schmidt A, Vetter I, Wirth M, Heun P, Thomae AW, Imhof A. Proteomics. 2014 May 19. doi: 10.1002/pmic.201400052.

The histone variant H2A.Bbd is enriched at sites of DNA synthesis. Sansoni V, Casas-Delucchi CS, Rajan M, Schmidt A, Bönisch C, Thomae AW, Staege MS, Hake SB, Cardoso MC, Imhof A. Nucleic Acids Res. 2014;42(10):6405-20.

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate. Schmitt ML, Ladwein KI, Carlino L, Schulz-Fincke J, Willmann D, Metzger E, Schilcher P, Imhof A, Schüle R, Sippl W, Jung M. J Biomol Screen. 2014 Mar 31.

Mislocalization of the Centromeric Histone Variant CenH3/CENP-A in Human Cells Depends on the Chaperone DAXX Lacoste, N., Woolfe, A., Tachiwana, H., Garea, A.V., Barth, T., Cantaloube, S., Kurumizaka, H., Imhof, A., and Almouzni, G. (2014). Mol. Cell 53, 631–644.

Circadian Control of Fatty Acid Elongation by SIRT1-mediated Deacetylation of Acetyl-CoA Synthetase 1. Sahar S, Masubuchi S, Eckel-Mahan K, Vollmer S, Galla L, Ceglia N, Masri S, Barth TK, Grimaldi B, Oluyemi O, Astarita G, Hallows WC, Piomelli D, Imhof A, Baldi P, Denu JM, Sassone-Corsi P. J Biol Chem. 2014 Jan 14.

Epstein Barr Virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation. Hernando H, Islam A, Rodriguez-Ubreva J, Forne I, Ciudad L, Imhof A, Shannon-Lowe C, Ballestar E. Nucleic Acids Research 2014 Jan 7;42(1):249-63.


A pair of centromeric proteins mediates reproductive isolation in Drosophila species. Thomae AW, Schade GOM, Padeken J, Borath M, Vetter I, Kremmer E, Heun P, Imhof A. Dev Cell 2013 Nov 25;27(4):412-24.

RNA-interference components are dispensable for transcriptional silencing of the drosophila bithorax-complex. Cernilogar FM, Burroughs AM, Lanzuolo C, Breiling A, Imhof A, Orlando V. PLoS One. 2013 Jun 13;8(6):e65740.

Stepwise evolution of essential centromere function in a Drosophila neogene. Ross BD, Rosin L, Thomae AW, Hiatt MA, Vermaak D, de la Cruz AF, Imhof A, Mellone BG, Malik HS. Science. 2013 Jun 7;340(6137):1211-4.

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations. Mori K, Lammich S, Mackenzie IR, Forné I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C. Acta Neuropathol. 2013 Mar;125(3):413-23.

The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Gazda L, Pokrzywa W, Hellerschmied D, Löwe T, Forné I, Mueller-Planitz F, Hoppe T, Clausen T. Cell 2013 Jan 17;152(1-2):183-95.

The circadian acetylome reveals regulation of mitochondrial metabolic pathways. Masri S, Patel VR, Kristin L. Eckel-Mahan KL, Peleg S, Forné I, Ladurner A, Baldi P, Imhof A, Sassone-Corsi P. PNAS 2013 Feb 26;110(9):3339-44

Mouse cytomegalovirus egress protein pM50 interacts with cellular endophilin-A2. Lemnitzer F, Raschbichler V, Kolodziejczak D, Israel L, Imhof A, Bailer SM, Koszinowski U, Ruzsics Z. Cell Microbiol. 2013 Feb;15(2):335-51.


Characterization of the insertase for β-barrel proteins of the outer mitochondrial membrane. Klein A, Israel L, Lackey SW, Nargang FE, Imhof A, Baumeister W, Neupert W, Thomas DR. J Cell Biol. 2012 Nov 12;199(4):599-611.

MSL2 Combines Sensor and Effector Functions in Homeostatic Control of the Drosophila Dosage Compensation Machinery. Villa R, Forné I, Müller M, Imhof A, Straub T, Becker PB. Mol Cell. 2012 Oct 16. doi:pii: S1097-2765(12)00788-5. 10.1016/j.molcel.2012.09.012. [Epub ahead of print]

Df31 Protein and snoRNAs Maintain Accessible Higher-Order Structures of Chromatin. Schubert T, Pusch MC, Diermeier S, Benes V, Kremmer E, Imhof A, Längst G. Mol Cell. 2012 Nov 9;48(3):434-44.

Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria. Schreiner B, Westerburg H, Forné I, Imhof A, Neupert W, Mokranjac D. Mol Biol Cell. 2012 Nov;23(22):4335-46.

DOT1A-dependent H3K76 methylation is required for replication regulation in Trypanosoma brucei. Gassen A, Brechtefeld D, Schandry N, Arteaga-Salas JM, Israel L, Imhof A and Janzen CJ.  Nucleic Acids Research, 2012, 1–10 doi:10.1093/nar/gks801 [Epub ahead of print]

Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation. Nübling G, Levin J, Bader B, Israel L, Bötzel K, Lorenzl S, Giese A. Exp Neurol. 2012 Oct;237(2):470-6. doi: 10.1016/j.expneurol.2012.07.018. Epub 2012 Aug 6.

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF. EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173.

Myb-binding protein 1a (Mybbp1a) regulates levels and processing of Pre-ribosomal RNA. Hochstatter J, Holzel M, Rohrmoser M, Schermelleh L, Leonhardt H, Keough R, Gonda TJ, Imhof A, Eick D, Langst G, Nemeth A. J Biol Chem. 2012 May 29.

Impairment of prostate cancer cell growth by a selective and reversible LSD1 inhibitor. Willmann D, Lim S, Wetzel S, Metzger E, Jandausch A, Wilk W, Jung M, Forné I, Imhof A, Janzer A, Kirfel J, Waldmann H, Schüle R, Buettner R. Int J Cancer. 2012 Mar 24.

Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry. Forné I, Ludwigsen J, Imhof A, Becker PB, Mueller-Planitz F. Mol Cell Proteomics. 2012 Apr;11(4):M111.012088.

Developmental Regulation of N-terminal H2B Methylation in Drosophila Melanogaster. Villar-Garea A, Forné I, Vetter I, Kremmer E, Thomae A, Imhof A. Nucleic Acids Res. 2012 Feb;40(4):1536-49


Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. Schneider TD, Arteaga-Salas JM, Mentele E, David R, Nicetto D, Imhof A, Rupp RA. PLoS One. 2011;6(7):e22548.

The RSC chromatin remodelling enzyme has a unique role in directing the accurate positioning of nucleosomes. Wippo CJ, Israel L, Watanabe S, Hochheimer A, Peterson CL, Korber P. EMBO J. 2011 Apr 6;30(7):1277-88

Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. Gruschke S, Kehrein K, Römpler K, Gröne K, Israel L, Imhof A, Herrmann JM, Ott M. J Cell Biol. 2011 Jun 13;193(6):1101-14.

The RNA Helicase Rm62 Cooperates with SU(VAR)3-9 to Re-Silence Active Transcription in Drosophila melanogaster. Boeke J., Bag I., Ramaiah MJ, Vetter I., Kremmer E., Pal-Bhadra M., Bhadra U. and Imhof A. PLOSone 2011 6(6): e20761

Sequential establishment of marks on soluble histones H3 and H4. Alvarez F, Munoz F, Schilcher P, Imhof A, Almozuni G, and Loyola A. JBC 2011 286 (20) 17714–17721

H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation. Guillemette B, Drogaris P, Lin H-HS, Armstrong H, Hiragami-Hamada K, Imhof A, Bonneil E, Thibault P, Verreault A, Festenstein RJ. PLoS Genet 2011 7(3): e1001354.

Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Obermeier B, Lovato L, Mentele R, Brück W, Forné I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O’Connor KC, Dornmair K. J Neuroimmunol. 2011 Feb 23

Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Pröbstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, Villalobos A, Breithaupt C, Weissert R, Jacob U, Krumbholz M, Kuempfel T, Blaschek A, Stark W, Gärtner J, Pohl D, Rostasy K, Weber F, Forné I, Khademi M, Olsson T, Brilot F, Tantsis E, Dale RC, Wekerle H, Hohlfeld R, Banwell B, Bar-Or A, Meinl E, Derfuss T. Neurology. 2011 Aug 9;77(6):580-8.


Proteins at the polypeptide tunnel exit of the yeast mitochondrial ribosome. Gruschke S, Gröne K, Heublein M, Hölz S, Israel L, Imhof A, Herrmann JM, Ott M. J Biol Chem. 2010 Jun 18;285(25):19022-8.

Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1. Boeke J, Regnard C, Cai W, Johansen J, Johansen KM, Becker PB and Imhof A. PLOSone 2010 Apr 6;5(4):e10042.

Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin. Illner D, Zinner R, Handtke V, Rouquette J, Strickfaden H, Lanctot C, Conrad M, Seiler A, Imhof A, Cremer T, Cremer M. Exp Cell Res. (2010) 316 (10), 1662-80.

Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y. Wiedemann SM, Mildner SN, Bönisch C, Israel L, Maiser A, Matheisl S, Straub T, Merkl R, Leonhardt H, Kremmer E, Schermelleh L, Hake SB. J Cell Biol. 2010 Sep 6;190(5):777-91.

Characterisation of the CipC-like protein AFUA_5G09330 of the opportunistic human pathogenic mould Aspergillus fumigatus. Bauer B, Schwienbacher M, Broniszewska M, Israel L, Heesemann J, Ebel F. Mycoses. 2010 Jul;53(4):296-304.

Phosphorylation of histone H3T6 by PKCbI controls demethylation at histone H3K4. Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, Müller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Günther T, Buettner R, Schüle R. Nature 2010 Mar 14.

Replication Stress Interferes With Histone Recycling And Pre-Deposition Marking Of New Histones. Jasencakova Z, Scharf A, Ask K, Corpet A, Imhof A, Almouzni G, Groth A. Mol.Cell (2010) Mar 12;37(5):736-743.


Interaction of HP1 and Brg1/Brm with the Globular Domain of Histone H3 Is Required for HP1-Mediated Repression. Lavigne M, Eskeland R, Azebi S, Saint-André V, Jang SM, Batsché E, Fan HY, Kingston RE, Imhof A, Muchardt C. PLoS Genet. 2009 Dec;5(12):e1000769.

Establishment of Histone Modifications after Chromatin Assembly. Scharf AN, Barth TK, Imhof A. Nucleic Acids Res. 2009 Jun 18.

Dynamics of adaptive microevolution of Pseudomonas aeruginosa hypermutators during long-term infection of the cystic fibrosis lung. Hoboth C, Hoffmann R, Eichner A, Henke C, Schmoldt S, Imhof A, Heesemann J, Hogardt M. Journal of Infectious Diseases 2009 Jul 1;200(1):118-30.

The HP1α-CAF-1-SetDB1 complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin. Loyola A, Tagami H, Bonaldi T, Roche D, Quivy JP2, Imhof A, Nakatani Y, Dent SYR, and Almouzni G. EMBO reports 2009;10(7):769-75.

Synergistic action of CD26/DPP-IV inhibition and G-CSF enhances homing of stem cells and improves ventricular function after acute myocardial infarction. Zaruba MM, Theiss HD, Vallaster M, Mehl U, Brunner S, David R, Fischer R, Krieg L, Hirsch E, Huber B, Nathan P, Israel L, Imhof A, Herbach N, Assmann G, Wanke R, Mueller-Hoecker J, Steinbeck G, Franz WM. Cell Stem Cell, Volume 4, Issue 4, 313-323, 3 April 2009.

Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc. Abel J, Eskeland R, Raffa GD, Kremmer E, Imhof A. PLoS ONE. 2009;4(4):e5089. Epub 2009 Apr 7.

Cross-talk between type three secretion system and metabolism in Yersinia. Schmid A, Neumayer W, Trülzsch K, Israel L, Imhof A, Roessle M, Sauer G, Richter S, Lauw S, Eylert E, Eisenreich W, Heesemann J, Wilharm G. J. J. Biol Chem. (2009) Feb 25.

Monomethylation of lysine 20 on histone H4 facilitates chromatin maturation. Scharf AN, Meier K, Seitz V, Kremmer E, Brehm A, and Imhof A. Mol Cell Biol (2009) 29, 57-67.

Salermide, a Sirtuin inhibitor with a strong cancer specific proapoptotic effect. Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Imhof A, Mato JM, Esteller M, Fraga MF. Oncogene  (2009) Feb 12;28(6):781-91.

Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases. Levin J, Giese A, Boetzel K, Israel L, Högen T, Nübling G, Kretzschmar H, Lorenzl S. Exp Neurol. 2009 Jan;215(1):201-8.


Analysis of histone modifications by mass spectrometry. Villar-Garea A, Israel L, Imhof A. Curr Protoc Protein Sci. 2008 Feb; Chapter 14:Unit 14.10.

ESC, ESCL and their roles in Polycomb Group mechanisms. Ohno K, McCabe D, Czermin B, Imhof A and Pirrotta V. Mech Dev. (2008) Jan 12.

Fine Mapping of posttranslational histone H1 modifications of Drosophila melanogaster. Villar-Garea A, Imhof A. PLOSone (2008) Feb 6;3(2):e1553.


Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. Bell O, Wirbelauer C, Hild M, Scharf AN, Schwaiger M, MacAlpine DM, Zilbermann F, van Leeuwen F, Bell SP, Imhof A, Garza D, Peters AH, Schübeler D. EMBO J. (2007) Dec 12;26(24):4974-84.

PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Hyllus D, Stein C, Schnabel K, Schiltz E, Imhof A, Dou Y, Hsieh J, Bauer UM. Genes Dev. (2007) Dec 15;21(24):3369-80.

OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria. Duvezin-Caubet S, Koppen M, Wagener J, Zick M, Israel L, Bernacchia A, Jagasia R, Rugarli EI, Imhof A, Neupert W, Langer T, Reichert AS. Mol Biol Cell. 2007 Sep;18(9):3582-90.

Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signaling. Pauly B, Lasi M, MacKintosh C, Morrice N, Imhof A, Regula R, Rudd S, David CN and Bottger A. BMC Cell Biology (2007) 2007 Jul 25;8:31.

Site-specific acetylation of ISWI by GCN5. Ferreira R, Eberharter A, Bonaldi T, Chioda M, Imhof A and Becker PB. BMC Molecular Biology (2007) Aug 30;8(1):73.

The proteome of the heterocyst cell wall in Anabaena sp. PCC 7120. Moslavac S, Reisinger V, Berg M, Mirus O, Vosyka O, Plöscher M, Flores E, Eichacker LA, Schleiff E. Biol Chem. 2007 Aug;388(8):823-90.

Proteomic approach for characterization of hop-inducible proteins in Lactobacillus brevis. Behr J, Israel L, Ganzle MG, Vogel RF. Appl Environ Microbiol. 2007 May;73(10):3300-6.

Activation of RNA polymerase I transcription by Cockayne Syndrome group B (CSB) protein and histone methyltransferase G9a. Yuan X, Feng W, Imhof A, Grummt I, and Zhou Y. Mol Cell (2007)  27 585-59.

Mass Spectrometric Analysis of Protein Histidine Phosphorylation. Zu XL, Besant PG, Imhof A, Attwood PV. Amino Acids (2007) 32(3):347-57.

Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha, beta, and gamma secretase. Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, and Lichtenthaler SF. J. Biol. Chem., 2007 Apr 20;282(16):11982-95.

HP1 binding to Chromatin methylated at H3K9 is enhanced by auxiliary factors. Eskeland R, Eberharter A, Imhof A. Mol Cell Biol. 2007 Jan;27(2):453-65.

Yersinia protein kinase YopO is activated by a novel G-actin binding process.  Trasak C, Zenner G, Vogel A, Yuksekdag G, Rost R, Haase I, Fischer M, Israel L, Imhof A, Linder S, Schleicher M, Aepfelbacher M. J Biol Chem. 2007 Jan 26;282(4):2268-77.

Functional characterization of Mia40p, the central component of the disulfide relay system of the mitochondrial intermembrane space. Grumbt B, Stroobant V, Terziyska N, Israel L, Hell K. J Biol Chem. 2007 Dec 28;282(52):37461-70.


PTMs on H3 Variants before Chromatin Assembly Potentiate Their Final Epigenetic State. Loyola A, Bonaldi T, Roche D, Imhof A, Almouzni G. Mol. Cell 2006 Oct 20;24(2):309-16.

Clonal analysis of Inquilinus limosus isolates from six cystic fibrosis patients and specific serum antibody response. Schmoldt S, Latzin P, Heesemann J, Griese M, Imhof A, Hogardt M. J Med Microbiol. 2006 Oct;55(Pt 10):1425-33.

A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Bohland C, Imhof A, Martoglio B, Teplow DB, Haass C. Nat Cell Biol. 2006 Aug;8(8):894-6.

Biochemical properties of UspG, a universalstress protein of Esherichia coli. Weber, A. and Jung, K. Biochemistry 2006, 45 1620-1628.

Time dependent proteome alterations under osmotic stress during aerobic and anaerobic growth conditions in scherichia coli. Weber A, Kögl S and Jung K. J. Bacteriol. 2006 188, 7165-7175.

Analysis of the regulation, expression and localisation of the isocitrate lyase from Aspergillus fumigatus a potenial target for antifungal drug development. Ebel F, Schwienbacher M, Beyer J, Heesemann J, Brakhage AA. Fungal genetics and Biology 43: 476-89 (2006).

Proteome analysis of mitochondrial outer membrane from Neurospora crassa. Schmitt S, Schlunck T, Camp II DG, Ahting U, Neupert W, Meitinger T, Imhof A, Oefner PJ, Prokisch H Rapaport D. Proteomics 2006 Jan;6(1):72-80.

Lipids join the post-genomic era. Bauer R, Imhof A. Genome Biology (2006) 7:330.

The Analysis of Histone Modifications. Villar-Garea A, Imhof A. Biochim Biophys Acta. 2006 Aug 26; [Epub ahead of print].

Epigenetic regulators and histone modification. Imhof A. Briefings in functional Genomics and Proteomics 2006 Sep;5(3):222-7.


Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Perez-Rosado A, Calvo E, Lopez JA, Cano A, Calasanz MJ, Colomer D, Piris MA, Ahn N, Imhof A, Caldas C, Jenuwein T, Esteller M. Nat Genet. 2005 Apr;37(4):391-400.

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A. Nature Chemical Biology (2005) 1, 143-145.

hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Taipale M, Rea S, Richter K, Vilar A, Lichter P, Imhof A, Akhtar A. Mol Cell Biol. 2005 Aug;25(15):6798-81.

Asp f6, an Aspergillus allergen specifically recognized by IgE from patients with allergic bronchopulmonary aspergillosis, is differentially expressed during germination. Schwienbacher M, Israel L, Heesemann J, Ebel F. Allergy. 2005 Nov;60(11):1430-5.

Assembly of the TOB complex of mitochondria. Habib SJ, Waizenegger T, Lech M, Neupert W, Rapaport D. J. Biol. Chem. (2005) 280, 6434-6440.

Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions. Terziyska N, Lutz T, Kozany C, Mokranjac D, Meseke N, Neupert W, Herrmann JM, Hell K. FEBS Lett. (2005) 579, 179-184.

Maitenenace of structure and function of mitochondrial Hsp70 chaperone requires the chaperone Hep1. Sichting M, Mokranjac D, Azem A, Neupert W, Hell K. EMBO J (2005) 24 1046-1056.


Native E2F/RBF complexes contain Myb interacting proteins and repress transcription of developmentally controlled E2F target genes. Korenjak M, Taylor-Harding B, Binné UK, Satterlee JS, Stevaux O, Aasland R, White-Cooper H, Dyson N and Brehm A. Cell 2004 Oct 15;119(2):181-93.

Yersinia enterolitica type III secretion: evidence for the ability to transport proteins that are folded prior to secretion. Wilharm G, Lehmann V, Neumeyer W, Trcek J, Heesemann J. BMC Microbiology 4:27 (2004).

The use of mass spectrometry for the analysis of histone modifications. Bonaldi T, Regula JT, Imhof A. Methods Enzymol. 2004;377:111-30.

A combination of different mass spectroscopic techniques for the analysis of dynamic changes of histone modifications. Bonaldi T, Imhof A, Regula JT. Proteomics. 2004 May;4(5):1382-96.

The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity. Eskeland R, Czermin B, Boeke J, Bonaldi T, Regula JT, Imhof A. Biochemistry. 2004 Mar 30;43(12):3740-9.

Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C. EMBO J. 2004 Aug 4;23(15):3041-50.

Differential effects of Parkinson’s disease-associated mutations on stability and folding of DJ-1. Gorner K, Holtorf E, Odoy S, Nuscher B, Yamamoto A, Regula JT, Beyer K, Haass C, Kahle PJ. J Biol Chem. 2004 Feb 20;279(8):6943-51.


Reconstitution of gamma-secretase activity. Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Nat Cell Biol. 2003 May;5(5):486-8.

Architecture of initiation competent 12 subunit RNA polymerase II. Armache KJ, Kettenberger H, Cramer P. PNAS (2003) 100, 6964-6968.