Publications
2024
PLK1-mediated phosphorylation cascade activates Mis18 complex to ensure centromere inheritance. Parashara P, Medina-Pritchard B, Abad MA, Sotelo-Parrilla P, Thamkachy R, Grundei D, Zou J, Spanos C, Kumar CN, Basquin C, Das V, Yan Z, Al-Murtadha AA, Kelly DA, McHugh T, Imhof A, Rappsilber J, Jeyaprakash AA.Science. 2024 Sep 6;385(6713):1098-1104.
Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling. Cheng J, Li M, Motta E, Barci D, Song W, Zhou D, Li G, Zhu S, Yang A, Vaillant BD, Imhof A, Forné I, Spiegl-Kreinecker S, Zhang N, Katayama H, Bhat KPL, Flüh C, Kälin RE, Glass R.Cell Rep Med. 2024 Aug 20;5(8):101658.
Metabolic plasticity in a Pde6bSTOP/STOP retinitis pigmentosa mouse model following rescue. Ayten M, Díaz-Lezama N, Ghanawi H, Haffelder FC, Kajtna J, Straub T, Borso M, Imhof A, Hauck SM, Koch SF.Mol Metab. 2024 Oct;88:101994.
Enhanced In Situ Spatial Proteomics by Effective Combination of MALDI Imaging and LC-MS/MS.
Schäfer F, Tomar A, Sato S, Teperino R, Imhof A, Lahiri S.Mol Cell Proteomics. 2024 Aug;23(8):100811. doi: 10.1016/j.mcpro.2024.100811.
LINC01021 Attenuates Expression and Affects Alternative Splicing of a Subset of p53-Regulated Genes.
Kaller M, Forné I, Imhof A, Hermeking H.Cancers (Basel). 2024 Apr 24;16(9):1639. doi: 10.3390/cancers16091639.PMID: 38730591 .
The role of RNA in the maintenance of chromatin domains as revealed by antibody-mediated proximity labelling coupled to mass spectrometry.
Choudhury R, Venkateswaran Venkatasubramani A, Hua J, Borsò M, Franconi C, Kinkley S, Forné I, Imhof A.Elife. 2024 May 8;13:e95718. doi: 10.7554/eLife.95718.PMID: 38717135 .
Decrypting the functional design of unmodified translation elongation factor P.
Tomasiunaite U, Kielkowski P, Krafczyk R, Forné I, Imhof A, Jung K.Cell Rep. 2024 May 28;43(5):114063.
Processivity and specificity of histone acetylation by the male-specific lethal complex.
Kiss AE, Venkatasubramani AV, Pathirana D, Krause S, Sparr AC, Hasenauer J, Imhof A, Müller M, Becker PB.Nucleic Acids Res. 2024 May 22;52(9):4889-4905.
Ribosome inactivation regulates translation elongation in neurons.
Popper B, Bürkle M, Ciccopiedi G, Marchioretto M, Forné I, Imhof A, Straub T, Viero G, Götz M, Schieweck R.J Biol Chem. 2024 Feb;300(2):105648.
Nuclear Hsp104 safeguards the dormant translation machinery during quiescence. Kohler V, Kohler A, Berglund LL, Hao X, Gersing S, Imhof A, Nyström T, Höög JL, Ott M, Andréasson C, Büttner S.Nat Commun. 2024 Jan 5;15(1):315.
Reduced oxygen concentrations regulate the phenotype and function of human granulosa cells in vitro and cause a diminished steroidogenic but increased inflammatory cellular reaction. Höfner M, Eubler K, Herrmann C, Berg U, Berg D, Welter H, Imhof A, Forné I, Mayerhofer A.Mol Hum Reprod. 2023 Dec 24;30(1):gaad049.
13
Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens.Kardell O, von Toerne C, Merl-Pham J, König AC, Blindert M, Barth TK, Mergner J, Ludwig C, Tüshaus J, Eckert S, Müller SA, Breimann S, Giesbertz P, Bernhardt AM, Schweizer L, Albrecht V, Teupser D, Imhof A, Kuster B, Lichtenthaler SF, Mann M, Cox J, Hauck SM.J Proteome Res. 2024 Jan 5;23(1):117-129. d
Synthesis and Structure Elucidation of Glutamyl-Queuosine.
Pichler A, Hillmeier M, Heiss M, Peev E, Xefteris S, Steigenberger B, Thoma I, Müller M, Borsò M, Imhof A, Carell T.J Am Chem Soc. 2023 Nov 29;145(47):25528-25532.
The fruit fly acetyltransferase chameau promotes starvation resilience at the expense of longevity.
Venkatasubramani AV, Ichinose T, Kanno M, Forne I, Tanimoto H, Peleg S, Imhof A.EMBO Rep. 2023 Oct 9;24(10):e57023. doi: 10.15252/embr.202357023.
PD-1 instructs a tumor-suppressive metabolic program that restricts glycolysis and restrains AP-1 activity in T cell lymphoma.
Wartewig T, Daniels J, Schulz M, Hameister E, Joshi A, Park J, Morrish E, Venkatasubramani AV, Cernilogar FM, van Heijster FHA, Hundshammer C, Schneider H, Konstantinidis F, Gabler JV, Klement C, Kurniawan H, Law C, Lee Y, Choi S, Guitart J, Forne I, Giustinani J, Müschen M, Jain S, Weinstock DM, Rad R, Ortonne N, Schilling F, Schotta G, Imhof A, Brenner D, Choi J, Ruland J.Nat Cancer. 2023 Oct;4(10):1508-1525.
DNA mimic foldamers affect chromatin composition and disturb cell cycle progression.
Kleene V, Corvaglia V, Chacin E, Forne I, Konrad DB, Khosravani P, Douat C, Kurat CF, Huc I, Imhof A.Nucleic Acids Res. 2023 Oct 13;51(18):9629-9642.
Comparison of clean catch and bag urine using LC-MS/MS proteomics in infants. Klaus R, Barth TK, Imhof A, Thalmeier F, Lange-Sperandio B.Pediatr Nephrol. 2024 Jan;39(1):203-212. doi: 10.1007/s00467-023-06098-3.
2023
RNA polymerase II CTD is dispensable for transcription and required for termination in human cells. Yahia Y, Pigeot A, El Aabidine AZ, Shah N, Karasu N, Forné I, Krebs S, Blum H, Esnault C, Sexton T, Imhof A, Eick D, Andrau JC.EMBO Rep. 2023 Sep 6;24(9):e56150. doi: 10.15252/embr.202256150.
20
Epigenetic dosage identifies two major and functionally distinct β cell subtypes.Dror E, Fagnocchi L, Wegert V, Apostle S, Grimaldi B, Gruber T, Panzeri I, Heyne S, Höffler KD, Kreiner V, Ching R, Tsai-Hsiu Lu T, Semwal A, Johnson B, Senapati P, Lempradl A, Schones D, Imhof A, Shen H, Pospisilik JA.Cell Metab. 2023 May 2;35(5):821-836.e7. doi: 10.1016/j.cmet.2023.03.008. Epub 2023 Mar 21.PMID: 36948185
A unified classification approach rating clinical utility of protein biomarkers across neurologic diseases.Bernhardt AM, Tiedt S, Teupser D, Dichgans M, Meyer B, Gempt J, Kuhn PH, Simons M, Palleis C, Weidinger E, Nübling G, Holdt L, Hönikl L, Gasperi C, Giesbertz P, Müller SA, Breimann S, Lichtenthaler SF, Kuster B, Mann M, Imhof A, Barth T, Hauck SM, Zetterberg H, Otto M, Weichert W, Hemmer B, Levin J.EBioMedicine. 2023 Mar;89:104456. doi: 10.1016/j.ebiom.2023.104456. Epub 2023 Feb 4.PMID: 36745974 . Review.
23
SPRTN patient variants cause global-genome DNA-protein crosslink repair defects.Weickert P, Li HY, Götz MJ, Dürauer S, Yaneva D, Zhao S, Cordes J, Acampora AC, Forne I, Imhof A, Stingele J.Nat Commun. 2023 Jan 21;14(1):352. doi: 10.1038/s41467-023-35988-1.PMID: 36681662 .
24
Improving SWATH-MS analysis by deep-learning.Sun B, Smialowski P, Aftab W, Schmidt A, Forne I, Straub T, Imhof A.Proteomics. 2023 May;23(9):e2200179. doi: 10.1002/pmic.202200179. Epub 2023 Jan 3.PMID: 36571325
25
2022
Statistical biases due to anonymization evaluated in an open clinical dataset from COVID-19 patients. Koll CEM, Hopff SM, Meurers T, Lee CH, Kohls M, Stellbrink C, Thibeault C, Reinke L, Steinbrecher S, Schreiber S, Mitrov L, Frank S, Miljukov O, Erber J, Hellmuth JC, Reese JP, Steinbeis F, Bahmer T, Hagen M, Meybohm P, Hansch S, Vadász I, Krist L, Jiru-Hillmann S, Prasser F, Vehreschild JJ; NAPKON Study Group.Sci Data. 2022 Dec 21;9(1):776. doi: 10.1038/s41597-022-01669-9.PMID: 36543828 .
26
Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones. Herbel SM, Moyon L, Christ M, Elsayed EM, Caffrey BE, Malmsheimer S, Grin I, Hoffmann K, Surmann K, Blankenburg S, Jung AL, Herkt CE, Borsò M, Bozdag B, Imhof A, Becker A, Wagner S, Bange G, Völker U, Bertrams W, Marsico A, Schmeck B.Virulence. 2022 Dec;13(1):2042-2058. doi: 10.1080/21505594.2022.2149973.PMID: 36411449 .
27
Probing protein ubiquitination in live cells. Qin W, Steinek C, Kolobynina K, Forné I, Imhof A, Cardoso MC, Leonhardt H.Nucleic Acids Res. 2022 Nov 28;50(21):e125. doi: 10.1093/nar/gkac805.PMID: 36189882 .
28
A multi-adenylate cyclase regulator at the flagellar tip controls African trypanosome transmission. Bachmaier S, Giacomelli G, Calvo-Alvarez E, Vieira LR, Van Den Abbeele J, Aristodemou A, Lorentzen E, Gould MK, Brennand A, Dupuy JW, Forné I, Imhof A, Bramkamp M, Salmon D, Rotureau B, Boshart M.Nat Commun. 2022 Sep 16;13(1):5445. doi: 10.1038/s41467-022-33108-z.PMID: 36114198 .
29
The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function. Nitz K, Lacy M, Bianchini M, Wichapong K, Kücükgöze IA, Bonfiglio CA, Migheli R, Wu Y, Burger C, Li Y, Forné I, Ammar C, Janjic A, Mohanta S, Duchene J, Heemskerk JWM, Megens RTA, Schwedhelm E, Huveneers S, Lygate CA, Santovito D, Zimmer R, Imhof A, Weber C, Lutgens E, Atzler D.Circ Res. 2022 Sep 30;131(8):701-712. doi: 10.1161/CIRCRESAHA.122.321094. Epub 2022 Sep 14.PMID: 36102188
30
Proteolytically generated soluble Tweak Receptor Fn14 is a blood biomarker for γ-secretase activity. Güner G, Aßfalg M, Zhao K, Dreyer T, Lahiri S, Lo Y, Slivinschi BI, Imhof A, Jocher G, Strohm L, Behrends C, Langosch D, Bronger H, Nimsky C, Bartsch JW, Riddell SR, Steiner H, Lichtenthaler SF.EMBO Mol Med. 2022 Oct 10;14(10):e16084. doi: 10.15252/emmm.202216084. Epub 2022 Sep 7.PMID: 36069059 .
Evidence of a role for cAMP in mitochondrial regulation in ovarian granulosa cells.
Kaseder M, Schmid N, Eubler K, Goetz K, Müller-Taubenberger A, Dissen GA, Harner M, Wanner G, Imhof A, Forne I, Mayerhofer A.Mol Hum Reprod. 2022 Sep 29;28(10):gaac030. doi: 10.1093/molehr/gaac030.PMID: 35944223 .
32
ImShot: An Open-Source Software for Probabilistic Identification of Proteins In Situ and Visualization of Proteomics Data. Aftab W, Lahiri S, Imhof A.Mol Cell Proteomics. 2022 Jun;21(6):100242. doi: 10.1016/j.mcpro.2022.100242. Epub 2022 May 13.PMID: 35569805 .
33
Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse.Müller-Eigner A, Sanz-Moreno A, de-Diego I, Venkatasubramani AV, Langhammer M, Gerlini R, Rathkolb B, Aguilar-Pimentel A, Klein-Rodewald T, Calzada-Wack J, Becker L, Palma-Vera S, Gille B, Forne I, Imhof A, Meng C, Ludwig C, Koch F, Heiker JT, Kuhla A, Caton V, Brenmoehl J, Reyer H, Schoen J, Fuchs H, Gailus-Durner V, Hoeflich A, de Angelis MH, Peleg S.Commun Biol. 2022 May 3;5(1):408. doi: 10.1038/s42003-022-03339-3.PMID: 35505192 .
34
Serial Changes in Exercise Capacity, NT-proBNP, and Adiponectin in Patients with Acute Coronary Syndrome before and after Phase II Rehabilitation as well as at the 12-Month Follow-Up. Jin H, Liu Y, Schweikert B, Hahman H, Wang L, Imhof A, Muche R, König W, Steinacker JM.Cardiol Res Pract. 2022 Jan 24;2022:6538296. doi: 10.1155/2022/6538296. eCollection 2022.PMID: 35111341 .
35
2021
Morc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation. Groh S, Milton AV, Marinelli LK, Sickinger CV, Russo A, Bollig H, de Almeida GP, Schmidt A, Forné I, Imhof A, Schotta G.Nat Commun. 2021 12(1):5996.
Discovery of Native Protein Complexes by Liquid Chromatography Followed by Quantitative Mass Spectrometry. Aftab W, Imhof A.Adv Exp Med Biol. 2021;1336:105-128.
The Integrity of the HMR complex is necessary for centromeric binding and reproductive isolation in Drosophila. Lukacs A, Thomae AW, Krueger P, Schauer T, Venkatasubramani AV, Kochanova NY, Aftab W, Choudhury R, Forne I, Imhof A.PLoS Genet. 2021 Aug 23;17(8):e1009744.
Phosphorylation of the HP1β hinge region sequesters KAP1 in heterochromatin and promotes the exit from naïve pluripotency. Qin W, Ugur E, Mulholland CB, Bultmann S, Solovei I, Modic M, Smets M, Wierer M, Forné I, Imhof A, Cardoso MC, Leonhardt H.Nucleic Acids Res. 2021 49(13):7406-7423.
Investigation and Highly Accurate Prediction of Missed Tryptic Cleavages by Deep Learning. Sun B, Smialowski P, Straub T, Imhof A.J Proteome Res. 2021 J20(7):3749-3757.
Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities.
Hayn M, Hirschenberger M, Koepke L, Nchioua R, Straub JH, Klute S, Hunszinger V, Zech F, Prelli Bozzo C, Aftab W, Christensen MH, Conzelmann C, Müller JA, Srinivasachar Badarinarayan S, Stürzel CM, Forne I, Stenger S, Conzelmann KK, Münch J, Schmidt FI, Sauter D, Imhof A, Kirchhoff F, Sparrer KMJ.Cell Rep. 2021 35(7):109126.
Exploring the Ion Channel TRPV2 and Testicular Macrophages in Mouse Testis.
Eubler K, Rantakari P, Gerke H, Herrmann C, Missel A, Schmid N, Walenta L, Lahiri S, Imhof A, Strauss L, Poutanen M, Mayerhofer A.Int J Mol Sci. 2021 22(9):4727.
Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice. Murenu E, Kostidis S, Lahiri S, Geserich AS, Imhof A, Giera M, Michalakis S.Int J Mol Sci. 2021 2345.
Helicobacter hepaticus is required for immune targeting of bacterial heat shock protein 60 and fatal colitis in mice. Friedrich V, Forné I, Matzek D, Ring D, Popper B, Jochum L, Spriewald S, Straub T, Imhof A, Krug A, Stecher B, Brocker T.Gut Microbes. 2021 13(1)
Reduced peroxisomal import triggers peroxisomal retrograde signaling. Rackles E, Witting M, Forné I, Zhang X, Zacherl J, Schrott S, Fischer C, Ewbank JJ, Osman C, Imhof A, Rolland SG.Cell Rep. 2021 34(3)
MALDI-IMS combined with shotgun proteomics identify and localize new factors in male infertility. Lahiri S, Aftab W, Walenta L, Strauss L, Poutanen M, Mayerhofer A, Imhof A.Life Sci Alliance. 2021 4(3)
Endotoxinemia Accelerates Atherosclerosis Through Electrostatic Charge-Mediated Monocyte Adhesion. Schumski A, Ortega-Gómez A, Wichapong K, Winter C, Lemnitzer P, Viola JR, Pinilla-Vera M, Folco E, Solis-Mezarino V, Völker-Albert M, Maas SL, Pan C, Perez Olivares L, Winter J, Hackeng T, Karlsson MCI, Zeller T, Imhof A, Baron RM, Nicolaes GAF, Libby P, Maegdefessel L, Kamp F, Benoit M, Döring Y, Soehnlein O.Circulation. 2021 43(3):254-266.
2020
Structure and Function of an Elongation Factor P Subfamily in Actinobacteria. Pinheiro,B., Scheidler,C.M., Kielkowski,P., Schmid,M., Forne,I., Ye,S., Reiling,N., Takano,E., Imhof,A., Sieber,S.A., et al. (2020) CellReports, 30, 4332–4342.e5.
Msp1 cooperates with the proteasome for extraction of arrested mitochondrial import intermediates. Basch,M., Wagner,M., Rolland,S., Carbonell,A., Zeng,R., Khosravi,S., Schmidt,A., Aftab,W., Imhof,A., Wagener,J., et al. (2020) Msp1 cooperates with the proteasome for extraction of arrested mitochondrial import intermediates. Mol. Biol. Cell, 31, 753–767.
Molecular Wiring of a Mitochondrial Translational Feedback Loop. Salvatori,R., Kehrein,K., Singh,A.P., Aftab,W., Möller-Hergt,B.V., Forne,I., Imhof,A. and Ott,M. (2020) Mol. Cell, 77, 887–900.e5.
A multi-layered structure of the interphase chromocenter revealed by proximity-based biotinylation. Kochanova,N.Y., Schauer,T., Mathias,G.P., Lukacs,A., Schmidt,A., Flatley,A., Schepers,A., Thomae,A.W. and Imhof,A. (2020) Nucleic Acids Res, 225, 912.
Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes. Alabert,C., Loos,C., Voelker-Albert,M., Graziano,S., Forne,I., Reverón-Gómez,N., Schuh,L., Hasenauer,J., Marr,C., Imhof,A., et al. (2020) CellReports, 30, 1223–1234.e8.
Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes. Alabert,C., Loos,C., Voelker-Albert,M., Graziano,S., Forne,I., Reverón-Gómez,N., Schuh,L., Hasenauer,J., Marr,C., Imhof,A., et al. (2020) CellReports, 30, 1223–1234.e8.
Chromosome organization by a conserved condensin-ParB system in the actinobacterium Corynebacterium glutamicum. Böhm,K., Giacomelli,G., Schmidt,A., Imhof,A., Koszul,R., Marbouty,M. and Bramkamp,M. (2020) Nat Commun, 11, 1485–17.
Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1. Minderjahn,J., Schmidt,A., Fuchs,A., Schill,R., Raithel,J., Babina,M., Schmidl,C., Gebhard,C., Schmidhofer,S., Mendes,K., et al. (2020) Nat Commun, 11, 402–16.
2019
Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake. Gaucher,J., Kinouchi,K., Ceglia,N., Montellier,E., Peleg,S., Greco,C.M., Schmidt,A., Forne,I., Masri,S., Baldi,P., et al. (2019) Proc Natl Acad Sci USA, 116, 25250–25259.
Distinct CoREST complexes act in a cell-type-specific manner. Mačinković,I., Theofel,I., Hundertmark,T., Kovač,K., Awe,S., Lenz,J., Forne,I., Lamp,B., Nist,A., Imhof,A., Stiewe T., Renkawitz-Pohl R., Rathke C., Brehm A. (2019) Nucleic Acids Res, 47, 11649–11666.
Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase. Lauterbach,M.A., Hanke,J.E., Serefidou,M., Mangan,M.S.J., Kolbe,C.-C., Hess,T., Rothe,M., Kaiser,R., Hoss,F., Gehlen,J., Engels G., Kreutzenbeck M., Schmidt S.V., Christ A., Imhof A., Hiller K., Latz E. (2019) Immunity, 51, 997–1011.e7.
Analog-sensitive cell line identifies cellular substrates of CDK9. Decker,T.-M., Forne,I., Straub,T., Elsaman,H., Ma,G., Shah,N., Imhof,A. and Eick,D. (2019) Oncotarget, 10, 6934–6943.
STATegra, a comprehensive multi-omics dataset of B-cell differentiation in mouse. Gomez-Cabrero,D., Tarazona,S., Ferreirós-Vidal,I., Ramirez,R.N., Company,C., Schmidt,A., Reijmers,T., Paul,V.V.S., Marabita,F., Rodriguez-Ubreva,J., et al. (2019) Sci Data, 6, 256–15.
Determining histone H4 acetylation patterns in human peripheral blood mononuclear cells using mass spectrometry. Bux,E.M., Solis-Mezarino,V., Kuhm,C., Northoff,B.H., Karin,I., Klopstock,T., Holdt,L.M., Völker-Albert,M., Imhof,A. and Peleg,S. (2019) Clinical Mass Spectrometry, 10.1016/j.clinms.2019.08.001.
Quantification of Proteins and Histone Marks in Drosophila Embryos Reveals Stoichiometric Relationships Impacting Chromatin Regulation. Bonnet, J., Lindeboom, R.G.H., Pokrovsky, D., Stricker, G., Çelik, M.H., Rupp, R.A.W., Gagneur, J., Vermeulen, M., Imhof, A., and Müller, J. (2019). Dev Cell 1–20.
Drosophila cell-free system that senses DNA breaks and triggers phosphorylation signalling. Harpprecht L, Baldi S, Schauer T, Schmidt A, Bange T, Robles MS, Kremmer E, Imhof A, Becker PB. A Nucleic Acids Res. 2019 May 31.
SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres. Gauchier M, Kan S, Barral A, Sauzet S, Agirre E, Bonnell E, Saksouk N, Barth TK, Ide S, Urbach S, Wellinger RJ, Luco RF, Imhof A, Déjardin J. Sci Adv. 2019 May 8;5(5):eaav3673.
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells. Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A, Allen A, Sum M, Obier N, Cottard F, Ulferts S, Preca BT, Hermann B, Maurer J, Greschik H, Hornung V, Einsle O, Perner S, Imhof A, Jung M, Schüle R. Nat Struct Mol Biol. 2019 May;26(5):361-371.
Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Bachmaier S, Volpato Santos Y, Kramer S, Githure GB, Klöckner T, Pepperl J, Baums C, Schenk R, Schwede F, Genieser HG, Dupuy JW, Forné I, Imhof A, Basquin J, Lorentzen E, Boshart M. Nat Commun. 2019 Mar 29;10(1):1421.
Multi-Reference Spectral Library Yields Almost Complete Coverage of Heterogeneous LC-MS/MS Data Sets. Ammar C, Berchtold E, Csaba G, Schmidt A, Imhof A, Zimmer R. J Proteome Res. 2019 Apr 5;18(4):1553-1566.
MIR sequences recruit zinc finger protein ZNF768 to expressed genes. Rohrmoser M, Kluge M, Yahia Y, Gruber-Eber A, Maqbool MA, Forné I, Krebs S, Blum H, Greifenberg AK, Geyer M, Descostes N, Imhof A, Andrau JC, Friedel CC, Eick D. Nucleic Acids Res. 2019 Jan 25;47(2):700-715.
2018
Shelterin and subtelomeric DNA sequences control nucleosome maintenance and genome stability. van Emden TS., Forn M., Forné I., Sarkadi Z., Capella M., Martín Caballero L., Fischer-Burkart S., Brönner C., Simonetta M., Toczyski D., Halic M., Imhof A., Braun S. (2018). EMBO Rep.
Importance of Pyruvate Sensing and Transport for the Resuscitation of Viable but Nonculturable Escherichia coli K-12. Vilhena C., Kaganovitch E., Grünberger A., Motz M., Forné I., Kohlheyer D., Jung K. (2018). J Bacteriology.
Detection of Histone Modification Dynamics during the Cell Cycle by MS-Based Proteomics. Völker-Albert MC., Schmidt A., Barth TK., Forné I., Imhof A. (2018). Methods Mol Biol.
Analysis of Histone Modifications by Mass Spectrometry. Völker-Albert MC., Schmidt A., Forné I., Imhof A. (2018). Curr Protoc Protein Sci.
Structural Architecture of the Nucleosome Remodeler ISWI Determined from Cross-Linking, Mass Spectrometry, SAXS, and Modeling. Harrer N., Schindler CEM., Bruetzel LK., Forné I., Ludwigsen J., Imhof A., Zacharias M., Lipfert J., Mueller-Planitz F. (2018). Structure.
Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals. Shah N., Maqbool MA., Yahia Y., El Aabidine AZ., Esnault C., Forné I., Decker TM., Martin D., Schüller R., Krebs S., Blum H., Imhof A., Eick D., Andrau JC. (2018). Mol Cell.
Regulation and function of H3K36 di-methylation by the trithorax-group protein complex AMC. Schmähling S., Meiler A., Lee Y., Mohammed A., Finkl K., Tauscher K., Israel L., Wirth M., Philippou-Massier J., Blum H., Habermann B., Imhof A., Song JJ., Müller J. (2018).Development.
PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex. Link S., Spitzer RMM., Sana M., Torrado M., Völker-Albert MC., Keilhauer EC., Burgold T., Pünzeler S., Low JKK., Lindström I., Nist A., Regnard C., Stiewe T., Hendrich B., Imhof A., Mann M., Mackay JP., Bartkuhn M., Hake SB. (2018). Nat Commun.
2017
Ubiquitome Analysis Reveals PCNA-Associated Factor 15 (PAF15) as a Specific Ubiquitination Target of UHRF1 in Embryonic Stem Cells. Karg E., Smets M., Ryan J., Forné I., Qin W., Mulholland CB., Kalideris G., Imhof A., Bultmann S., Leonhardt H. (2017). J Mol Biol.
PP32 and SET/TAF-Iβ proteins regulate the acetylation of newly synthesized histone H4. Saavedra F., Rivera C., Rivas E., Merino P., Garrido D., Hernández S., Forné I., Vassias I., Gurard-Levin ZA., Alfaro IE., Imhof A., Almouzni G., Loyola A. (2017). Nucleic Acids Res.
Coronin 1A., a novel player in integrin biology., controls neutrophil trafficking in innate immunity. Pick R., Begandt D., Stocker TJ., Salvermoser M., Thome S., Böttcher RT., Montanez E., Harrison U., Forné I., Khandoga AG., Coletti R., Weckbach LT., Brechtefeld D., Haas R., Imhof A., Massberg S., Sperandio M., Walzog B. (2017).Blood.
Concerted regulation of ISWI by an autoinhibitory domain and the H4 N-terminal tail. Ludwigsen J., Pfennig S., Singh AK., Schindler C., Harrer N., Forné I., Zacharias M., Mueller-Planitz F. (2017). Elife.
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex. Saredi G., Huang H., Hammond CM., Alabert C., Bekker-Jensen S., Forné I., Reverón-Gómez N., Foster BM., Mlejnkova L., Bartke T., Cejka P., Mailand N., Imhof A., Patel DJ., Groth A. (2017). Nature.
ATM induces MacroD2 nuclear export upon DNA damage. Golia B., Moeller GK., Jankevicius G., Schmidt A., Hegele A., Preißer J., Tran ML., Imhof A., Timinszky G. (2017). Nucleic Acids Res.
Adrenergic Signaling Strengthens Cardiac Myocyte Cohesion. Schinner C., Vielmuth F., Rötzer V., Hiermaier M., Radeva MY., Co TK., Hartlieb E., Schmidt A., Imhof A., Messoudi A., Horn A., Schlipp A., Spindler V., Waschke J. (2017). Circ Res.
NO Augments Endothelial Reactivity by Reducing Myoendothelial Calcium Signal Spreading: A Novel Role for Cx37 (Connexin 37) and the Protein Tyrosine Phosphatase SHP-2. Pogoda K., Mannell H., Blodow S., Schneider H., Schubert KM., Qiu J., Schmidt A., Imhof A., Beck H., Tanase LI., Pfeifer A., Pohl U., Kameritsch P. (2017). Arterioscler Thromb Vasc Biol.
2016
Specific threonine-4 phosphorylation and function of RNA polymerase II CTD during M phase progression. Hintermair C., Voß K., Forné I., Heidemann M., Flatley A., Kremmer E., Imhof A., Eick D. (2016). Sci Rep.
Heptad-Specific Phosphorylation of RNA Polymerase II CTD. Schüller R.*, Forné I.*, Straub T.*, Schreieck A., Texier Y., Shah N., Decker TM., Cramer P., Imhof A., Eick D. (2016). Mol Cell.
Life span extension by targeting a link between metabolism and histone acetylation in Drosophila. Peleg S., Feller C., Forné I., Schiller E., Sévin DC., Schauer T., Regnard C., Straub T., Prestel M., Klima C., Schmitt Nogueira M., Becker L., Klopstock T., Sauer U., Becker PB., Imhof A., Ladurner AG. (2016) EMBO Rep.
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation. Metzger E., Willmann D., McMillan J., Forné I., Metzger P., Gerhardt S., Petroll K., von Maessenhausen A., Urban S., Schott AK., Espejo A., Eberlin A., Wohlwend D., Schüle KM., Schleicher M., Perner S., Bedford MT., Jung M., Dengjel J., Flaig R., Imhof A., Einsle O., Schüle R. (2016) Nat Struct Mol Biol.
In situ detection of histone variants and modifications in mouse brain using imaging mass spectrometry. Lahiri S., Sun N., Solis-Mezarino V., Fedisch A., Ninkovic J., Feuchtinger A., Götz M., Walch A., Imhof A. (2016) Proteomics.
MALDI imaging mass spectrometry as a novel tool for detecting histone modifications in clinical tissue samples. Lahiri S., Sun N., Buck A., Imhof A., Walch A. (2016) Expert Rev Proteomics.
Combinatorial Histone Acetylation Patterns Are Generated by Motif-Specific Reactions. Blasi T., Feller C., Feigelman J., Hasenauer J., Imhof A., Theis FJ., Becker PB., Marr C. (2016). Cell Syst.
A Quantitative Proteomic Analysis of In Vitro Assembled Chromatin. Völker-Albert MC., Pusch MC., Fedisch A., Schilcher P., Schmidt A., Imhof A. (2016). Mol Cell Proteomics.
2015
Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II. Voss K., Forné I., Descostes N., Hintermair C., Schüller R., Maqbool MA., Heidemann M., Flatley A., Imhof A., Gut M., Gut I., Kremmer E., Andrau JC., Eick D. (2015) Transcription.
Cdc42-dependent actin dynamics controls maturation and secretory activity of dendritic cells. Schulz AM., Stutte S., Hogl S., Luckashenak N., Dudziak D., Leroy C., Forné I., Imhof A., Müller SA., Brakebusch CH., Lichtenthaler SF., Brocker T. (2015) .J Cell Biol.
DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex. Kellner, M., Rohrmoser, M., Forné, I., Voss, K., Burger, K., Mühl, B., Gruber-Eber, A., Kremmer, E., Imhof, A., and Eick, D. (2015). Experimental Cell Research.
DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination. Qin, W., Wolf, P., Liu, N., Link, S., Smets, M., Mastra, F.L., Forne, I., Pichler, G., Hörl, D., Fellinger, K., et al. (2015). Cell Res. 25, 911–929.
Methylation of histone H3 lysine 9 occurs during translation. Rivera, C., Saavedra, F., Alvarez, F., Díaz-Celis, C., Ugalde, V., Li, J., Forne, I., Gurard-Levin, Z.A., Almouzni, G., Imhof, A., et al. (2015). Nucleic Acids Res 43, 9097–9106.
The Epoxyeicosatrienoic Acid Pathway Enhances Hepatic Insulin Signaling and is Repressed in Insulin-Resistant Mouse Liver. Schäfer, A., Neschen, S., Kahle, M., Sarioglu, H., Gaisbauer, T., Imhof, A., Adamski, J., Hauck, S.M., and Ueffing, M. (2015). Molecular & Cellular Proteomics 14, 2764–2774.
Two distinct modes for propagation of histone PTMs across the cell cycle. Alabert, C., Barth, T.K., Reverón-Gómez, N., Sidoli, S., Schmidt, A., Jensen, O.N., Imhof, A., and Groth, A. (2015). Genes Dev. 29, 585–590.
Global and specific responses of the histone acetylome to systematic perturbation. Feller, C., Forné, I., Imhof, A., and Becker, P.B. (2015). Mol. Cell 57, 559–571.
2014
PRK1/PKN1 controls migration and metastasis of androgen-independent prostate cancer cells. Jilg CA, Ketscher A, Metzger E, Hummel B, Willmann D, Rüsseler V, Drendel V, Imhof A, Jung M, Franz H, Hölz S, Krönig M, Müller JM, Schüle R. Oncotarget. 2014 Dec 10. [Epub ahead of print]
Redundant Mechanisms to Form Silent Chromatin at Pericentromeric Regions Rely on BEND3 and DNA Methylation. Saksouk N, Barth TK, Ziegler-Birling C, Olova N, Nowak A, Rey E, Mateos-Langerak J, Urbach S, Reik W, Torres-Padilla ME, Imhof A, Déjardin J. Mol Cell. 2014 Nov 20;56(4):580-94
The novel component Kgd4 recruits the E3 subunit to the mitochondrial α-ketoglutarate dehydrogenase. Heublein M, Burguillos MA, Vögtle FN, Teixeira PF, Imhof A, Meisinger C, Ott M. Mol Biol Cell. 2014 Nov 1;25(21):3342-9.
LSD1 controls metastasis of androgen-independent prostate cancer cells through PXN and LPAR6. Ketscher A, Jilg CA, Willmann D, Hummel B, Imhof A, Rüsseler V, Hölz S, Metzger E, Müller JM, Schüle R. Oncogenesis. 2014 Oct 6;3:e120.
Bioinformatic analysis of proteomics data. Schmidt A, Forne I, Imhof A. BMC Syst Biol. 2014 Mar 13;8(Suppl 2):S3. Epub 2014 Mar 13.
Epigenetic reprogramming of cortical neurons through alteration of dopaminergic circuits. Brami-Cherrier K, Anzalone A, Ramos M, Forne I, Macciardi F, Imhof A, Borrelli E. Mol Psychiatry. 2014 Jul 15. doi: 10.1038/mp.2014.67.
Identification of novel Drosophila centromere associated proteins. Barth TK, Schade GO, Schmidt A, Vetter I, Wirth M, Heun P, Thomae AW, Imhof A. Proteomics. 2014 May 19. doi: 10.1002/pmic.201400052.
The histone variant H2A.Bbd is enriched at sites of DNA synthesis. Sansoni V, Casas-Delucchi CS, Rajan M, Schmidt A, Bönisch C, Thomae AW, Staege MS, Hake SB, Cardoso MC, Imhof A. Nucleic Acids Res. 2014;42(10):6405-20.
Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate. Schmitt ML, Ladwein KI, Carlino L, Schulz-Fincke J, Willmann D, Metzger E, Schilcher P, Imhof A, Schüle R, Sippl W, Jung M. J Biomol Screen. 2014 Mar 31.
Mislocalization of the Centromeric Histone Variant CenH3/CENP-A in Human Cells Depends on the Chaperone DAXX Lacoste, N., Woolfe, A., Tachiwana, H., Garea, A.V., Barth, T., Cantaloube, S., Kurumizaka, H., Imhof, A., and Almouzni, G. (2014). Mol. Cell 53, 631–644.
Circadian Control of Fatty Acid Elongation by SIRT1-mediated Deacetylation of Acetyl-CoA Synthetase 1. Sahar S, Masubuchi S, Eckel-Mahan K, Vollmer S, Galla L, Ceglia N, Masri S, Barth TK, Grimaldi B, Oluyemi O, Astarita G, Hallows WC, Piomelli D, Imhof A, Baldi P, Denu JM, Sassone-Corsi P. J Biol Chem. 2014 Jan 14.
Epstein Barr Virus-mediated transformation of B cells induces global chromatin changes independent to the acquisition of proliferation. Hernando H, Islam A, Rodriguez-Ubreva J, Forne I, Ciudad L, Imhof A, Shannon-Lowe C, Ballestar E. Nucleic Acids Research 2014 Jan 7;42(1):249-63.
2013
A pair of centromeric proteins mediates reproductive isolation in Drosophila species. Thomae AW, Schade GOM, Padeken J, Borath M, Vetter I, Kremmer E, Heun P, Imhof A. Dev Cell 2013 Nov 25;27(4):412-24.
RNA-interference components are dispensable for transcriptional silencing of the drosophila bithorax-complex. Cernilogar FM, Burroughs AM, Lanzuolo C, Breiling A, Imhof A, Orlando V. PLoS One. 2013 Jun 13;8(6):e65740.
Stepwise evolution of essential centromere function in a Drosophila neogene. Ross BD, Rosin L, Thomae AW, Hiatt MA, Vermaak D, de la Cruz AF, Imhof A, Mellone BG, Malik HS. Science. 2013 Jun 7;340(6137):1211-4.
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations. Mori K, Lammich S, Mackenzie IR, Forné I, Zilow S, Kretzschmar H, Edbauer D, Janssens J, Kleinberger G, Cruts M, Herms J, Neumann M, Van Broeckhoven C, Arzberger T, Haass C. Acta Neuropathol. 2013 Mar;125(3):413-23.
The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Gazda L, Pokrzywa W, Hellerschmied D, Löwe T, Forné I, Mueller-Planitz F, Hoppe T, Clausen T. Cell 2013 Jan 17;152(1-2):183-95.
The circadian acetylome reveals regulation of mitochondrial metabolic pathways. Masri S, Patel VR, Kristin L. Eckel-Mahan KL, Peleg S, Forné I, Ladurner A, Baldi P, Imhof A, Sassone-Corsi P. PNAS 2013 Feb 26;110(9):3339-44
Mouse cytomegalovirus egress protein pM50 interacts with cellular endophilin-A2. Lemnitzer F, Raschbichler V, Kolodziejczak D, Israel L, Imhof A, Bailer SM, Koszinowski U, Ruzsics Z. Cell Microbiol. 2013 Feb;15(2):335-51.
2012
Characterization of the insertase for β-barrel proteins of the outer mitochondrial membrane. Klein A, Israel L, Lackey SW, Nargang FE, Imhof A, Baumeister W, Neupert W, Thomas DR. J Cell Biol. 2012 Nov 12;199(4):599-611.
MSL2 Combines Sensor and Effector Functions in Homeostatic Control of the Drosophila Dosage Compensation Machinery. Villa R, Forné I, Müller M, Imhof A, Straub T, Becker PB. Mol Cell. 2012 Oct 16. doi:pii: S1097-2765(12)00788-5. 10.1016/j.molcel.2012.09.012. [Epub ahead of print]
Df31 Protein and snoRNAs Maintain Accessible Higher-Order Structures of Chromatin. Schubert T, Pusch MC, Diermeier S, Benes V, Kremmer E, Imhof A, Längst G. Mol Cell. 2012 Nov 9;48(3):434-44.
Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria. Schreiner B, Westerburg H, Forné I, Imhof A, Neupert W, Mokranjac D. Mol Biol Cell. 2012 Nov;23(22):4335-46.
DOT1A-dependent H3K76 methylation is required for replication regulation in Trypanosoma brucei. Gassen A, Brechtefeld D, Schandry N, Arteaga-Salas JM, Israel L, Imhof A and Janzen CJ. Nucleic Acids Research, 2012, 1–10 doi:10.1093/nar/gks801 [Epub ahead of print]
Limited cleavage of tau with matrix-metalloproteinase MMP-9, but not MMP-3, enhances tau oligomer formation. Nübling G, Levin J, Bader B, Israel L, Bötzel K, Lorenzl S, Giese A. Exp Neurol. 2012 Oct;237(2):470-6. doi: 10.1016/j.expneurol.2012.07.018. Epub 2012 Aug 6.
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. Kuhn PH, Koroniak K, Hogl S, Colombo A, Zeitschel U, Willem M, Volbracht C, Schepers U, Imhof A, Hoffmeister A, Haass C, Roßner S, Bräse S, Lichtenthaler SF. EMBO J. 2012 Jun 22;31(14):3157-68. doi: 10.1038/emboj.2012.173.
Myb-binding protein 1a (Mybbp1a) regulates levels and processing of Pre-ribosomal RNA. Hochstatter J, Holzel M, Rohrmoser M, Schermelleh L, Leonhardt H, Keough R, Gonda TJ, Imhof A, Eick D, Langst G, Nemeth A. J Biol Chem. 2012 May 29.
Impairment of prostate cancer cell growth by a selective and reversible LSD1 inhibitor. Willmann D, Lim S, Wetzel S, Metzger E, Jandausch A, Wilk W, Jung M, Forné I, Imhof A, Janzer A, Kirfel J, Waldmann H, Schüle R, Buettner R. Int J Cancer. 2012 Mar 24.
Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry. Forné I, Ludwigsen J, Imhof A, Becker PB, Mueller-Planitz F. Mol Cell Proteomics. 2012 Apr;11(4):M111.012088.
Developmental Regulation of N-terminal H2B Methylation in Drosophila Melanogaster. Villar-Garea A, Forné I, Vetter I, Kremmer E, Thomae A, Imhof A. Nucleic Acids Res. 2012 Feb;40(4):1536-49
2011
Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome. Schneider TD, Arteaga-Salas JM, Mentele E, David R, Nicetto D, Imhof A, Rupp RA. PLoS One. 2011;6(7):e22548.
The RSC chromatin remodelling enzyme has a unique role in directing the accurate positioning of nucleosomes. Wippo CJ, Israel L, Watanabe S, Hochheimer A, Peterson CL, Korber P. EMBO J. 2011 Apr 6;30(7):1277-88
Cbp3-Cbp6 interacts with the yeast mitochondrial ribosomal tunnel exit and promotes cytochrome b synthesis and assembly. Gruschke S, Kehrein K, Römpler K, Gröne K, Israel L, Imhof A, Herrmann JM, Ott M. J Cell Biol. 2011 Jun 13;193(6):1101-14.
The RNA Helicase Rm62 Cooperates with SU(VAR)3-9 to Re-Silence Active Transcription in Drosophila melanogaster. Boeke J., Bag I., Ramaiah MJ, Vetter I., Kremmer E., Pal-Bhadra M., Bhadra U. and Imhof A. PLOSone 2011 6(6): e20761
Sequential establishment of marks on soluble histones H3 and H4. Alvarez F, Munoz F, Schilcher P, Imhof A, Almozuni G, and Loyola A. JBC 2011 286 (20) 17714–17721
H3 Lysine 4 Is Acetylated at Active Gene Promoters and Is Regulated by H3 Lysine 4 Methylation. Guillemette B, Drogaris P, Lin H-HS, Armstrong H, Hiragami-Hamada K, Imhof A, Bonneil E, Thibault P, Verreault A, Festenstein RJ. PLoS Genet 2011 7(3): e1001354.
Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Obermeier B, Lovato L, Mentele R, Brück W, Forné I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O’Connor KC, Dornmair K. J Neuroimmunol. 2011 Feb 23
Antibodies to MOG are transient in childhood acute disseminated encephalomyelitis. Pröbstel AK, Dornmair K, Bittner R, Sperl P, Jenne D, Magalhaes S, Villalobos A, Breithaupt C, Weissert R, Jacob U, Krumbholz M, Kuempfel T, Blaschek A, Stark W, Gärtner J, Pohl D, Rostasy K, Weber F, Forné I, Khademi M, Olsson T, Brilot F, Tantsis E, Dale RC, Wekerle H, Hohlfeld R, Banwell B, Bar-Or A, Meinl E, Derfuss T. Neurology. 2011 Aug 9;77(6):580-8.
2010
Proteins at the polypeptide tunnel exit of the yeast mitochondrial ribosome. Gruschke S, Gröne K, Heublein M, Hölz S, Israel L, Imhof A, Herrmann JM, Ott M. J Biol Chem. 2010 Jun 18;285(25):19022-8.
Phosphorylation of SU(VAR)3-9 by the chromosomal kinase JIL-1. Boeke J, Regnard C, Cai W, Johansen J, Johansen KM, Becker PB and Imhof A. PLOSone 2010 Apr 6;5(4):e10042.
Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin. Illner D, Zinner R, Handtke V, Rouquette J, Strickfaden H, Lanctot C, Conrad M, Seiler A, Imhof A, Cremer T, Cremer M. Exp Cell Res. (2010) 316 (10), 1662-80.
Identification and characterization of two novel primate-specific histone H3 variants, H3.X and H3.Y. Wiedemann SM, Mildner SN, Bönisch C, Israel L, Maiser A, Matheisl S, Straub T, Merkl R, Leonhardt H, Kremmer E, Schermelleh L, Hake SB. J Cell Biol. 2010 Sep 6;190(5):777-91.
Characterisation of the CipC-like protein AFUA_5G09330 of the opportunistic human pathogenic mould Aspergillus fumigatus. Bauer B, Schwienbacher M, Broniszewska M, Israel L, Heesemann J, Ebel F. Mycoses. 2010 Jul;53(4):296-304.
Phosphorylation of histone H3T6 by PKCbI controls demethylation at histone H3K4. Metzger E, Imhof A, Patel D, Kahl P, Hoffmeyer K, Friedrichs N, Müller JM, Greschik H, Kirfel J, Ji S, Kunowska N, Beisenherz-Huss C, Günther T, Buettner R, Schüle R. Nature 2010 Mar 14.
Replication Stress Interferes With Histone Recycling And Pre-Deposition Marking Of New Histones. Jasencakova Z, Scharf A, Ask K, Corpet A, Imhof A, Almouzni G, Groth A. Mol.Cell (2010) Mar 12;37(5):736-743.
2009
Interaction of HP1 and Brg1/Brm with the Globular Domain of Histone H3 Is Required for HP1-Mediated Repression. Lavigne M, Eskeland R, Azebi S, Saint-André V, Jang SM, Batsché E, Fan HY, Kingston RE, Imhof A, Muchardt C. PLoS Genet. 2009 Dec;5(12):e1000769.
Establishment of Histone Modifications after Chromatin Assembly. Scharf AN, Barth TK, Imhof A. Nucleic Acids Res. 2009 Jun 18.
Dynamics of adaptive microevolution of Pseudomonas aeruginosa hypermutators during long-term infection of the cystic fibrosis lung. Hoboth C, Hoffmann R, Eichner A, Henke C, Schmoldt S, Imhof A, Heesemann J, Hogardt M. Journal of Infectious Diseases 2009 Jul 1;200(1):118-30.
The HP1α-CAF-1-SetDB1 complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin. Loyola A, Tagami H, Bonaldi T, Roche D, Quivy JP2, Imhof A, Nakatani Y, Dent SYR, and Almouzni G. EMBO reports 2009;10(7):769-75.
Synergistic action of CD26/DPP-IV inhibition and G-CSF enhances homing of stem cells and improves ventricular function after acute myocardial infarction. Zaruba MM, Theiss HD, Vallaster M, Mehl U, Brunner S, David R, Fischer R, Krieg L, Hirsch E, Huber B, Nathan P, Israel L, Imhof A, Herbach N, Assmann G, Wanke R, Mueller-Hoecker J, Steinbeck G, Franz WM. Cell Stem Cell, Volume 4, Issue 4, 313-323, 3 April 2009.
Drosophila HP1c is regulated by an auto-regulatory feedback loop through its binding partner Woc. Abel J, Eskeland R, Raffa GD, Kremmer E, Imhof A. PLoS ONE. 2009;4(4):e5089. Epub 2009 Apr 7.
Cross-talk between type three secretion system and metabolism in Yersinia. Schmid A, Neumayer W, Trülzsch K, Israel L, Imhof A, Roessle M, Sauer G, Richter S, Lauw S, Eylert E, Eisenreich W, Heesemann J, Wilharm G. J. J. Biol Chem. (2009) Feb 25.
Monomethylation of lysine 20 on histone H4 facilitates chromatin maturation. Scharf AN, Meier K, Seitz V, Kremmer E, Brehm A, and Imhof A. Mol Cell Biol (2009) 29, 57-67.
Salermide, a Sirtuin inhibitor with a strong cancer specific proapoptotic effect. Lara E, Mai A, Calvanese V, Altucci L, Lopez-Nieva P, Martinez-Chantar ML, Varela-Rey M, Rotili D, Nebbioso A, Ropero S, Montoya G, Oyarzabal J, Velasco S, Serrano M, Witt M, Villar-Garea A, Imhof A, Mato JM, Esteller M, Fraga MF. Oncogene (2009) Feb 12;28(6):781-91.
Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases. Levin J, Giese A, Boetzel K, Israel L, Högen T, Nübling G, Kretzschmar H, Lorenzl S. Exp Neurol. 2009 Jan;215(1):201-8.
2008
Analysis of histone modifications by mass spectrometry. Villar-Garea A, Israel L, Imhof A. Curr Protoc Protein Sci. 2008 Feb; Chapter 14:Unit 14.10.
ESC, ESCL and their roles in Polycomb Group mechanisms. Ohno K, McCabe D, Czermin B, Imhof A and Pirrotta V. Mech Dev. (2008) Jan 12.
Fine Mapping of posttranslational histone H1 modifications of Drosophila melanogaster. Villar-Garea A, Imhof A. PLOSone (2008) Feb 6;3(2):e1553.
2007
Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila. Bell O, Wirbelauer C, Hild M, Scharf AN, Schwaiger M, MacAlpine DM, Zilbermann F, van Leeuwen F, Bell SP, Imhof A, Garza D, Peters AH, Schübeler D. EMBO J. (2007) Dec 12;26(24):4974-84.
PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Hyllus D, Stein C, Schnabel K, Schiltz E, Imhof A, Dou Y, Hsieh J, Bauer UM. Genes Dev. (2007) Dec 15;21(24):3369-80.
OPA1 processing reconstituted in yeast depends on the subunit composition of the m-AAA protease in mitochondria. Duvezin-Caubet S, Koppen M, Wagener J, Zick M, Israel L, Bernacchia A, Jagasia R, Rugarli EI, Imhof A, Neupert W, Langer T, Reichert AS. Mol Biol Cell. 2007 Sep;18(9):3582-90.
Proteomic screen in the simple metazoan Hydra identifies 14-3-3 binding proteins implicated in cellular metabolism, cytoskeletal organisation and Ca2+ signaling. Pauly B, Lasi M, MacKintosh C, Morrice N, Imhof A, Regula R, Rudd S, David CN and Bottger A. BMC Cell Biology (2007) 2007 Jul 25;8:31.
Site-specific acetylation of ISWI by GCN5. Ferreira R, Eberharter A, Bonaldi T, Chioda M, Imhof A and Becker PB. BMC Molecular Biology (2007) Aug 30;8(1):73.
The proteome of the heterocyst cell wall in Anabaena sp. PCC 7120. Moslavac S, Reisinger V, Berg M, Mirus O, Vosyka O, Plöscher M, Flores E, Eichacker LA, Schleiff E. Biol Chem. 2007 Aug;388(8):823-90.
Proteomic approach for characterization of hop-inducible proteins in Lactobacillus brevis. Behr J, Israel L, Ganzle MG, Vogel RF. Appl Environ Microbiol. 2007 May;73(10):3300-6.
Activation of RNA polymerase I transcription by Cockayne Syndrome group B (CSB) protein and histone methyltransferase G9a. Yuan X, Feng W, Imhof A, Grummt I, and Zhou Y. Mol Cell (2007) 27 585-59.
Mass Spectrometric Analysis of Protein Histidine Phosphorylation. Zu XL, Besant PG, Imhof A, Attwood PV. Amino Acids (2007) 32(3):347-57.
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha, beta, and gamma secretase. Kuhn PH, Marjaux E, Imhof A, De Strooper B, Haass C, and Lichtenthaler SF. J. Biol. Chem., 2007 Apr 20;282(16):11982-95.
HP1 binding to Chromatin methylated at H3K9 is enhanced by auxiliary factors. Eskeland R, Eberharter A, Imhof A. Mol Cell Biol. 2007 Jan;27(2):453-65.
Yersinia protein kinase YopO is activated by a novel G-actin binding process. Trasak C, Zenner G, Vogel A, Yuksekdag G, Rost R, Haase I, Fischer M, Israel L, Imhof A, Linder S, Schleicher M, Aepfelbacher M. J Biol Chem. 2007 Jan 26;282(4):2268-77.
Functional characterization of Mia40p, the central component of the disulfide relay system of the mitochondrial intermembrane space. Grumbt B, Stroobant V, Terziyska N, Israel L, Hell K. J Biol Chem. 2007 Dec 28;282(52):37461-70.
2006
PTMs on H3 Variants before Chromatin Assembly Potentiate Their Final Epigenetic State. Loyola A, Bonaldi T, Roche D, Imhof A, Almouzni G. Mol. Cell 2006 Oct 20;24(2):309-16.
Clonal analysis of Inquilinus limosus isolates from six cystic fibrosis patients and specific serum antibody response. Schmoldt S, Latzin P, Heesemann J, Griese M, Imhof A, Hogardt M. J Med Microbiol. 2006 Oct;55(Pt 10):1425-33.
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Fluhrer R, Grammer G, Israel L, Condron MM, Haffner C, Friedmann E, Bohland C, Imhof A, Martoglio B, Teplow DB, Haass C. Nat Cell Biol. 2006 Aug;8(8):894-6.
Biochemical properties of UspG, a universalstress protein of Esherichia coli. Weber, A. and Jung, K. Biochemistry 2006, 45 1620-1628.
Time dependent proteome alterations under osmotic stress during aerobic and anaerobic growth conditions in scherichia coli. Weber A, Kögl S and Jung K. J. Bacteriol. 2006 188, 7165-7175.
Analysis of the regulation, expression and localisation of the isocitrate lyase from Aspergillus fumigatus a potenial target for antifungal drug development. Ebel F, Schwienbacher M, Beyer J, Heesemann J, Brakhage AA. Fungal genetics and Biology 43: 476-89 (2006).
Proteome analysis of mitochondrial outer membrane from Neurospora crassa. Schmitt S, Schlunck T, Camp II DG, Ahting U, Neupert W, Meitinger T, Imhof A, Oefner PJ, Prokisch H Rapaport D. Proteomics 2006 Jan;6(1):72-80.
Lipids join the post-genomic era. Bauer R, Imhof A. Genome Biology (2006) 7:330.
The Analysis of Histone Modifications. Villar-Garea A, Imhof A. Biochim Biophys Acta. 2006 Aug 26; [Epub ahead of print].
Epigenetic regulators and histone modification. Imhof A. Briefings in functional Genomics and Proteomics 2006 Sep;5(3):222-7.
2005
Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Fraga MF, Ballestar E, Villar-Garea A, Boix-Chornet M, Espada J, Schotta G, Bonaldi T, Haydon C, Ropero S, Petrie K, Iyer NG, Perez-Rosado A, Calvo E, Lopez JA, Cano A, Calasanz MJ, Colomer D, Piris MA, Ahn N, Imhof A, Caldas C, Jenuwein T, Esteller M. Nat Genet. 2005 Apr;37(4):391-400.
Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Greiner D, Bonaldi T, Eskeland R, Roemer E, Imhof A. Nature Chemical Biology (2005) 1, 143-145.
hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Taipale M, Rea S, Richter K, Vilar A, Lichter P, Imhof A, Akhtar A. Mol Cell Biol. 2005 Aug;25(15):6798-81.
Asp f6, an Aspergillus allergen specifically recognized by IgE from patients with allergic bronchopulmonary aspergillosis, is differentially expressed during germination. Schwienbacher M, Israel L, Heesemann J, Ebel F. Allergy. 2005 Nov;60(11):1430-5.
Assembly of the TOB complex of mitochondria. Habib SJ, Waizenegger T, Lech M, Neupert W, Rapaport D. J. Biol. Chem. (2005) 280, 6434-6440.
Mia40, a novel factor for protein import into the intermembrane space of mitochondria is able to bind metal ions. Terziyska N, Lutz T, Kozany C, Mokranjac D, Meseke N, Neupert W, Herrmann JM, Hell K. FEBS Lett. (2005) 579, 179-184.
Maitenenace of structure and function of mitochondrial Hsp70 chaperone requires the chaperone Hep1. Sichting M, Mokranjac D, Azem A, Neupert W, Hell K. EMBO J (2005) 24 1046-1056.
2004
Native E2F/RBF complexes contain Myb interacting proteins and repress transcription of developmentally controlled E2F target genes. Korenjak M, Taylor-Harding B, Binné UK, Satterlee JS, Stevaux O, Aasland R, White-Cooper H, Dyson N and Brehm A. Cell 2004 Oct 15;119(2):181-93.
Yersinia enterolitica type III secretion: evidence for the ability to transport proteins that are folded prior to secretion. Wilharm G, Lehmann V, Neumeyer W, Trcek J, Heesemann J. BMC Microbiology 4:27 (2004).
The use of mass spectrometry for the analysis of histone modifications. Bonaldi T, Regula JT, Imhof A. Methods Enzymol. 2004;377:111-30.
A combination of different mass spectroscopic techniques for the analysis of dynamic changes of histone modifications. Bonaldi T, Imhof A, Regula JT. Proteomics. 2004 May;4(5):1382-96.
The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity. Eskeland R, Czermin B, Boeke J, Bonaldi T, Regula JT, Imhof A. Biochemistry. 2004 Mar 30;43(12):3740-9.
Nicalin and its binding partner Nomo are novel Nodal signaling antagonists. Haffner C, Frauli M, Topp S, Irmler M, Hofmann K, Regula JT, Bally-Cuif L, Haass C. EMBO J. 2004 Aug 4;23(15):3041-50.
Differential effects of Parkinson’s disease-associated mutations on stability and folding of DJ-1. Gorner K, Holtorf E, Odoy S, Nuscher B, Yamamoto A, Regula JT, Beyer K, Haass C, Kahle PJ. J Biol Chem. 2004 Feb 20;279(8):6943-51.
2003
Reconstitution of gamma-secretase activity. Edbauer D, Winkler E, Regula JT, Pesold B, Steiner H, Haass C. Nat Cell Biol. 2003 May;5(5):486-8.
Architecture of initiation competent 12 subunit RNA polymerase II. Armache KJ, Kettenberger H, Cramer P. PNAS (2003) 100, 6964-6968.