Zentrallabor für Proteinanalytik (Protein Analysis Unit)
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Peptide characterisation

Sequencing of peptides by LC-MS/MS from proteins after protease digestion to validate sequences or to map cross-links.

Selected Examples

Peptide Validation

Related B cell clones that populate the CSF and CNS of patients with multiple sclerosis produce CSF immunoglobulin. Obermeier B, Lovato L, Mentele R, Brück W, Forné I, Imhof A, Lottspeich F, Turk KW, Willis SN, Wekerle H, Hohlfeld R, Hafler DA, O’Connor KC, Dornmair K. J Neuroimmunol. 2011 Feb 23

Crosslink mapping

The myosin chaperone UNC-45 is organized in tandem modules to support myofilament formation in C. elegans. Gazda L, Pokrzywa W, Hellerschmied D, Löwe T, Forné I, Mueller-Planitz F, Hoppe T, Clausen T. Cell 2013 Jan 17;152(1-2):183-95. doi: 10.1016/j.cell.2012.12.025

Probing the conformation of the ISWI ATPase domain with genetically encoded photoreactive crosslinkers and mass spectrometry. Forné I, Ludwigsen J, Imhof A, Becker PB, Mueller-Planitz F. Mol Cell Proteomics. 2012 Apr;11(4):M111.012088